Abc transporter5/29/2023 ![]() Impact on its function as membrane barrier. Clin Pharmacol Ther 75:422–433Īrana MR, Tocchetti GN, Rigalli JP, Mottino AD, Villanueva SSM (2016) Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Kidney Int 70:1019–1025Īnglicheau D, Thervet E, Etienne I, Hurault De Ligny B, Le Meur Y, Touchard G et al (2004) CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation. Endocrinology 147:3435–3445Īnglicheau D, Pallet N, Rabant M, Marquet P, Cassinat B, Méria P et al (2006) Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction. Haematologica 101:909–917Īndric SA, Kostic TS, Stojilkovic SS (2006) Contribution of multidrug resistance protein MRP5 in control of cyclic guanosine 5′-monophosphate intracellular signaling in anterior pituitary cells. Am J Physiol Gastrointest Liver Physiol 305:G314–G324Īndolfo I, Russo R, Manna F, De Rosa G, Gambale A, Zouwail S et al (2016) Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia. Essays Biochem 50:63–83Īl-Shboul Q, Mahavadi S, Sriwai W, Grider JR, Murthy KS (2013) Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle. Pharm Res 24:1803–1820Īl-Shawi MK (2011) Catalytic and transport cycles of ABC exporters. Biochem J 382:711–716Īlrefai WA, Gill RK (2007) Bile Acid transporters: structure, function, regulation and pathophysiological implications. Science 323:1718–1722Īlqawi O, Bates S, Georges E (2004) Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Cancer Chemother Pharmacol 69:1387–1391Īller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R et al (2009) Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Pflug Arch 453:581–589Īlexiou GA, Goussia A, Voulgaris S, Fotopoulos AD, Fotakopoulos G, Ntoulia A et al (2012) Prognostic significance of MRP5 immunohistochemical expression in glioblastoma. Biochem Biophys Res Commun 299:681–687Īlbrecht C, Viturro E (2007) The ABCA subfamily-Gene and protein structures, functions and associated hereditary diseases. Pharm Res 18:1119–1125Īkita H, Suzuki H, Sugiyama Y (2002) Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3. Stem Cells 26:810–818Īkita H, Suzuki H, Sugiyama Y (2001) Sinusoidal efflux of taurocholate is enhanced in Mrp 2-deficient rat liver. PLoS One 6:e25086Īhmed F, Arseni N, Glimm H, Hiddemann W, Buske C, Feuring-Buske M (2008) Constitutive expression of the ATP-binding cassette transporter ABCG2 enhances the growth potential of early human hematopoietic progenitors. Multidrug resistance-associated proteinsĪgnani D, Acharya P, Martinez E, Tran TT, Abraham F, Tobin F et al (2011) Fitting the elementary rate constants of the P-GP transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm.This chapter will describe function and expression of several ABC transporters (such as P-GP, BCRP, and MRPs), their substrates and inhibitors, as well as their clinical significance. Several human diseases such as cystic fibrosis, sitosterolemia, Tangier disease, intrahepatic cholestasis, and retinal degeneration are associated with mutations in corresponding transporters. Some ABC transporters are also involved in diverse cellular processes such as maintenance of osmotic homeostasis, antigen processing, cell division, immunity, cholesterol, and lipid trafficking. These ABC transporters are expressed in various tissues such as the liver, intestine, kidney, and brain, playing important roles in absorption, distribution, and excretion of drugs. Of them, at least 11 ABC transporters including P-glycoprotein (P-GP/ ABCB1), multidrug resistance-associated proteins (MRPs/ABCCs), and breast cancer resistance protein (BCRP/ ABCG2) are involved in multidrug resistance (MDR) development. More than 40 ABC transporters have been identified in human, which are divided into 7 subfamilies (ABCA to ABCG) based on their gene structure, amino acid sequence, domain organization, and phylogenetic analysis. One of the largest transporter families is the ATP-binding cassette (ABC) family. The processes are usually mediated by specific transporters. The transport of specific molecules across lipid membranes is an essential function of all living organisms. ![]()
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